The Catalysis and Chiral Technologies group of Johnson Matthey is pleased to present our redesigned monthly edition of Catalysis Forum. Our goal is to provide a convenient means for you to receive updates to out latest developments in catalysis. We value your input and welcome suggestions on specific areas of interest that you would like to see incorporated into our updates. We also invite you to share this information with your colleagues.
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New Developments in Palladium
Catalyzed Carbonylation
Due to the wide-ranging reactivity of -CHO functionality, step (and atom) economical methodologies for the preparation of aldehydes are extremely useful in route development for organic synthesis in the Pharmaceutical and Fine Chemical sectors.
Johnson Matthey has developed very practical methodologies in this area and provides a variety of catalysts for the carbonylation of arylhalides, triflates, mesylates and even tosylates to aldehydes, acids, esters and amides under relatively milder conditions.
For information on our Carbonylation Kit, click here.
Mechanism for Reductive Carbonylation
References:
C. F. J. Barnard, Organometallics 2008, 27, 5402-5422
Palladium-catalyzed carbonylation – a reaction come of age
C. F. J. Barnard, Org. Process. Res. Dev. 2008, 12, 566-574
Carbonylation of aryl halides: extending the scope of the reaction
L. Ashfield and C.F. J. Barnard, Org. Process Res. Dev. 2007, 11, 39-43
Reductive carbonylation – an efficient and practical route for the conversion of aryl halides to aldehydes
For additional technical information or to inquire about samples, please email us at CCT@jmusa.com
Scientific Update Conferences 2009
Process Analytical Technologies (PAT)
in Organic Process R&D
17 - 18 March 2009, Brussels, Belgium
Polymorphism & Crystallization:
Chemical Development Issues
19 - 20 March 2009, Brussels, Belgium
Complete details of these and the other conferences offered by Scientific Update are available here.
