Johnson Matthey Catalysis Forum

Lactobacillus brevis

A Versatile, Robust Catalyst for Enantioselective
Reduction of Ketones

The application of alcohol dehydrogenase from lactobacillus brevis (LbADH ) offers:

• Excellent activity for a wide substrate scope

• High regio- and enantioselectivity

• High solvent tolerance

Links:

LbADH Data Sheet

LbADH Applications

Journal references

Alcohol Dehydrogenase from Lactobacillus brevis: A Versatile Robust Catalyst for Enantioselective Transformations

S. Leuchsa and L. Greinera Chem. Biochem. Eng. Q. 25 (2) 267-281 (2011

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Additional References:

Biocatalytic Reduction of b,d-Diketo Esters: A Highly Stereoselective Approach to All Four Stereoisomers of a Chlorinated b,d-Dihydroxy Hexanoate – Click here to see the abstract

Michael Wolberg, Werner Hummel, and Michael Müller

Continuous asymmetric ketone reduction processes with recombinant Escherichia coli – Click here to see the abstract

Kirsten Schroer, Ursula Mackfeld, Ivy Ai Wei Tan, Christian Wandrey, Florian Heuser, Stephanie Bringer-Meyer, Andrea Weckbecker, Werner Hummel, Thomas Daußmann, Rupert Pfaller, Andreas Liese and Stephan Lütz,

Enantioselective Synthesis of Both Enantiomers of Various Propargylic Alcohols by Use of Two Oxidoreductases – Click here
to see the abstract

Thomas Schubert, Werner Hummel, Maria-Regina Kula,] and Michael Müller

For additional information on these catalysts, please contact us at Schlecx@jmusa.com