Ru-124 (1,5-cyclooctadiene)bis(2-Me-allyl)Ruthenium(II)

A versatile catalyst precursor  - Now available at commercial scale!

Excellent catalyst precursor in terms of  ease of activation to form a variety of catalysts with the
aid of various chiral/achiral ligands.

Solubility: Soluble in THF, Toluene, Pentane

Molecular Formula: C₁₆H₂₆Ru

Molecular Weight: 319.5

CAS: 12289-94-0

Ru-124

Applications

Stereoselective anti-Markovnikov-Addition to Alkynes

An in situ catalyst system generated from Ru(Me-allyl)₂(COD) with a phosphine ligand was found to efficiently catalyze addition of thioamides to terminal alkynes with exclusive formation of the anti-Markovnikov thioenamide products

L. J. Goossen, M. Blancho, K. S. Salih, R. Karch, A. Rivas-Nass   Org. Lett., 2008, 10, 4497

Enantioselective hydrogention of α,ß unsaturated acids

A useful catalyst precursor for making chiral bisphosphine based Ru acetate or trifluoroacteate catalysts, for example [Ru(COD)(CF₃COO₂]/ R-Xyl PhanePhos, a highly active and efficient catalytic system for the hydrogenation of an unsaturated acid.

G.A.Grasa, A.Zanotti-Gerosa, S. Ghosh, G.A.Teleha, W.A.Kinney, B.E.Maryanoff, Tet. Lett. 2008,  49,  5328

Enantioselective Hydrogenation of C=C double bonds in N-Boc-pyrroles

The first reported successful enantioselective hydrogenation of a pyrrole

R. Kuwano, M. Kashiwabara, M. Ohsumi, H. Kusano J. Am. Chem. Soc., 2008, 130, 808

Hydrogenation of cyclic or acyclic β-(acylamino)crylates

Ru(Me-allyl)2(COD) in conjunction with chiral biaryl ligands provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic β- amino acid derivatives.

W. Tang, S. Wu, X. Zhang J. Am. Chem. Soc., 2003, 125, 9570